{"id":423,"date":"2013-02-11T18:51:32","date_gmt":"2013-02-12T00:51:32","guid":{"rendered":"https:\/\/skepticink.com\/smilodonsretreat\/?p=423"},"modified":"2013-02-11T15:36:29","modified_gmt":"2013-02-11T21:36:29","slug":"ervs-evidence-for-evolution","status":"publish","type":"post","link":"https:\/\/skepticink.com\/smilodonsretreat\/2013\/02\/11\/ervs-evidence-for-evolution\/","title":{"rendered":"ERVs – Evidence for Evolution"},"content":{"rendered":"

Viruses are amazing things.\u00a0 I don’t think anyone would argue that they are actually living things.\u00a0 But they are extraordinarily complex systems and can have massive effects on organisms that as large to them as the a town is to us.\u00a0 Here’s a neat little animation<\/a> that shows the scale of some viruses.<\/p>\n

One particular class of virus is particularly interesting.\u00a0 We all should know about how most viruses work.\u00a0 They invade the cell, co-opt the organelles and make the cell do nothing but build new viruses.\u00a0 After some time, the cell dies, releasing all those new viruses into the host organism. The retroviruses are different.<\/p>\n

I hesitate to use the word ‘insidious’, because they aren’t.\u00a0 They are just doing what they do.\u00a0 But to us, it seems insidious.\u00a0 Instead of just invading the cell and co-opting the organelles, a retrovirus actually inserts DNA into the genome of the cell.<\/p>\n

A retrovirus is actually a RNA virus.\u00a0 The virus’s genetic material is stored as messenger RNA.\u00a0 The RNA is reverse transcribed into DNA in the host cell.\u00a0 Transcription is the process of forming an mRNA strand from DNA.\u00a0 Since the virus does the reverse, it’s a “retrovirus”.\u00a0 Retroviruses even have to bring a unique tool with them.\u00a0 The pol<\/em> gene is responsible for making the viral reverse transcriptase, since cellular enzymes can’t perform that function.<\/p>\n

So we have this unique mechanism in the retrovirus.\u00a0 But it gets more interesting.\u00a0 The viral DNA gets inserted into the host organism DNA.\u00a0 The cell then uses the viral DNA as a template for viral proteins.\u00a0 Instead of being co-opted, producing new viruses, and then dying, the cell lives it’s full life making new viral bodies along with everything else it’s supposed to do.<\/p>\n

If the virus attacks a gamete, then that viral genome can appear in every cell in the offspring’s body and be passed on to future generations.\u00a0 It sounds like a great deal for the virus.\u00a0 However, the viruses are very sensitive.\u00a0 Viral genomes are often very tight, very compact, and very susceptible to mutation.\u00a0 Humans and other plants and animals (and other species as well) have multiple copies of each gene.\u00a0 So, if one of those alleles is broken by mutation, there is a spare.\u00a0 Viruses and bacteria don’t have this feature.<\/p>\n

A mutation that damages the virus’s ability to perform any of the functions it must perform (invade a host cell, reverse transcribe the RNA, build the protein coat, etc) means that the virus is no longer effective.\u00a0 The entire genome is broken, the virus can no longer function, but the DNA is still there, in the host organism.<\/p>\n

That is called an endogenous retrovirus (ERV).<\/p>\n

How can this be evidence for evolution?\u00a0 Good question, I’m glad you asked.<\/p>\n

Let’s say an organism gets one of these ERVs in its gametes and passes that gene onto it’s offspring.\u00a0 Except the offspring ends up with a mutation that breaks the viral gene (crossing over for example).\u00a0 Now, that organism has a gene that doesn’t affect anything, but it’s there.*<\/p>\n

All of that organisms offspring will have a copy of that gene and, more telling, that gene will be in the same relative place.\u00a0 As time goes on and the species diverges, speciation events occur and mutations happen, a pattern will emerge.\u00a0 That pattern is the same as what is predicted for the idea of common descent.\u00a0 That is, organisms will share a common ancestor and those organisms that are more closely related will have a more recent common ancestor.<\/p>\n

A 2000 study of primates<\/a> shows this very well.\u00a0 All monkeys contain two particular ERVs.\u00a0 Another two ERVs are shared by all monkeys except new world monkeys.\u00a0 Three more are shared only by gibbons, orangutans.\u00a0 Another two are only shared between chimps, gorillas, and humans.\u00a0 And three more appear only in humans.\u00a0 This is but a tiny bit of the 30,000+ ERVs in our genome. A similar situation appears in felids.<\/p>\n

If common descent were not correct, then we would not expect to see dozens of species with the exact same viral remnant in the exact same genomic position. For example, it would be highly unlike to find a cat with the same two ERVs shared by humans, chimps and gorillas.<\/p>\n

If common descent were not correct, then we would not see a relationship between shared ERVs and the closeness of two species.\u00a0 The more closely related the organisms, the more ERVs they share.<\/p>\n

_______
\n* There is significant evidence that ERV remnants do affect expression of other genes and that organisms can co-opt the former viral genes as well.\u00a0 But go with me here.<\/p>\n","protected":false},"excerpt":{"rendered":"

Viruses are amazing things.\u00a0 I don’t think anyone would argue that they are actually living things.\u00a0 But they are extraordinarily…<\/p>\n","protected":false},"author":27,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,8,6],"tags":[275,938,49],"class_list":["post-423","post","type-post","status-publish","format-standard","hentry","category-biology","category-evolution","category-science","tag-erv","tag-evolution","tag-virus"],"_links":{"self":[{"href":"https:\/\/skepticink.com\/smilodonsretreat\/wp-json\/wp\/v2\/posts\/423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/skepticink.com\/smilodonsretreat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/skepticink.com\/smilodonsretreat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/skepticink.com\/smilodonsretreat\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/skepticink.com\/smilodonsretreat\/wp-json\/wp\/v2\/comments?post=423"}],"version-history":[{"count":0,"href":"https:\/\/skepticink.com\/smilodonsretreat\/wp-json\/wp\/v2\/posts\/423\/revisions"}],"wp:attachment":[{"href":"https:\/\/skepticink.com\/smilodonsretreat\/wp-json\/wp\/v2\/media?parent=423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/skepticink.com\/smilodonsretreat\/wp-json\/wp\/v2\/categories?post=423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/skepticink.com\/smilodonsretreat\/wp-json\/wp\/v2\/tags?post=423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}