{"id":167,"date":"2014-01-28T07:00:56","date_gmt":"2014-01-28T15:00:56","guid":{"rendered":"https:\/\/skepticink.com\/health\/?p=167"},"modified":"2014-01-27T20:41:35","modified_gmt":"2014-01-28T04:41:35","slug":"spoonful-sugar","status":"publish","type":"post","link":"https:\/\/skepticink.com\/health\/2014\/01\/28\/spoonful-sugar\/","title":{"rendered":"Where Truth Lies: Placebos"},"content":{"rendered":"
\n

By Reed Loring Levine, MD<\/b><\/p>\n

<\/b>Albert: “My hands are shaking…Agador, l need some Pirin tablets. Quickly!”<\/em><\/p>\n

Armand: “What are you giving him drugs for? What the hell are Pirin tablets?”<\/em><\/p>\n

Agador: “It’s aspirin with the ‘A’ and the ‘S’ scraped off.”<\/em><\/p>\n

Armand: “My God, what a brilliant idea!”<\/em><\/p>\n

\u00a0 \u00a0 -The Birdcage, 1996<\/p>\n<\/blockquote>\n

I can give you a treatment that significantly reduces the searing pain of shingles in about one-third of patients. \u00a0I can give you a pill that has been shown to significantly reduce depression in more than 50% of its users. \u00a0An erection pill that helps 24% of men produce erections of subjectively-better quality. \u00a0A migraine treatment that significantly reduces headache pain in 30-40% of patients…<\/p>\n

The thing is, none of these remedies\u00a0should work.<\/p>\n

Because they are all placebos.<\/p>\n

Each is the “control group” in a major study of an FDA-approved medication, and these placebos appear to produce significant benefit for many users.<\/p>\n

Placebos (traditionally defined as a medically-ineffective treatment) and the placebo effect (a perceived or actual outcome from a placebo) are well known, but most people know very little about how and why placebos work, how they can be tweaked or manipulated to alter our perceptions and behaviors.<\/p>\n

In casual conversation, an oncologist colleague told me that in the world of cancer treatment, patients commonly utilize \u201cholistic\u201d and \u201cnatural\u201d treatments to complement science-based care.\u00a0 She listed a half-dozen such things she commonly encountered, from prayer and ritualized meditation to many variant forms of \u201cjuicing\u201d.\u00a0 Many of the treatments her patients used were pseudo-scientific nutrition regimens focused on what they eat or drink.\u00a0 She expressed that her approach is that if a patient buys into a \u201cholistic\u201d diet and supplement or other such program\u00a0in addition to\u00a0<\/i>standard proven treatment that she will not only \u201clet it slide\u201d but encourage it. \u00a0Her patients are involved in a process in which they are in many ways powerless, having given over control to both their disease and their physicians.\u00a0 She believes\u00a0that the placebo effect of letting the patient feel some degree of control through these self-guided regimens is beneficial, although \u201cthe specifics of their regimen doesn\u2019t seem to matter at all.\u201d Perhaps there is such a frequent focus on rituals that involve food or supplements because cancer patients are often faced with long stretches where nausea and vomiting limits their intake, so any act where they can take control of what goes in their body takes on extra meaning for them, and when coupled with the idea that the food is itself a treatment, you have a set up for a potent placebo effect.<\/p>\n

There is good evidence that the placebo effect has a profound impact on clinical outcomes and can be manipulated.\u00a0 How can we leverage the existing data to ethically improve the medical care of patients?\u00a0 We know a few things, including:<\/p>\n

\n

1. It appears that being honest about placebos may not, in some cases, decrease their efficacy: you can sometimes tell people you are giving them placebos\u00a0and they still work<\/p>\n

2. Brand-name placebos are more effective than generics.<\/p>\n

3. Multiple-tablet placebo doses appear more effective than single-tablet doses<\/span><\/p>\n

4. Tablet color and shape matters. (ie: blue pills treat insomnia better than red pills; anxiety is best treated with green pills)<\/p>\n

5. Route of administration matters. (ie: tablets are less effective than capsules which are less effective than shots or medical devices)<\/span><\/p>\n

6. Costly treatments are more effective than inexpensive ones.<\/span><\/p>\n

7. The physician\u2019s description of what to expect has a great impact on the actual effect of the treatment.<\/span><\/p>\n

Keeping all of this in mind, a physician might ethically prescribe a treatment they believe has a good probability of working for patient\u2019s condition while utilizing this knowledge to enhance the probability of a positive effect and decrease the probability of adverse effects. Although it\u2019s not always advisable to prescribe non-generic drugs, in cases where a physician does so for a good reason they might spend time explaining to the patient the thought process for their decision and explain what benefits this brand-name, more costly treatment choice offers.\u00a0 If I am choosing a more expensive option for a patient, I should be able to justify my decision medically, and taking the time to explain that decision to my patient may actually enhance the effect of the treatment (Facts #2, #6 & #7, above).<\/p>\n

In clinical practice we often will have patients gradually taper up medications to a desired goal-dose.\u00a0 This is is typically done to reduce the incidence of side-effects.\u00a0 Explaining the taper using key phrases may theoretically enhance the benefits and reduce the side-effects, for instance, one might say, \u201cthis gentle tapering up on the medication will reduce the probability of side-effects, and may make any ones you have less severe, as you gradually work your way up to the full, effective dosage\u201d.<\/p>\n

Placebos and the placebo effect have a profound, often under-appreciated impact on both the practice of clinical medicine and, taken in a more broad sense, on a wide variety of our daily experiences.\u00a0 Over a series of short pieces, I will examine with you the literally-unreal landscape of placebos, from pharmaceutical testing, to quack-medicine, and beyond.\u00a0 I look forward to exploring these curious corners of human experience with you in the coming months.<\/p>\n

Special thanks to Greg Stikeleather, Jamy Ian Swiss and Max Maven,\u00a0<\/em>whose engaging dinner conversation helped inspire this series of articles.<\/em><\/p>\n

REFERENCES<\/strong><\/span><\/p>\n

    \n
  1. Conboy, LA, et al.\u00a0 Which patients improve: characteristics increasing sensitivity to a supportive patient-practitioner relationship.<\/b> Soc Sci Med. 2010 Feb;70(3):479-84. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19900742<\/a><\/li>\n
  2. de Craen, AJM, et al.\u00a0 Effect of colour of drugs: systematic review of perceived effect of drugs and of their effectiveness<\/b>.\u00a0 BMJ 1996;313:1624.\u00a0http:\/\/www.bmj.com\/content\/313\/7072\/1624<\/a><\/li>\n
  3. Howick J<\/a>..\u00a0 Saying things the “right” way: avoiding “nocebo” effects and providing full informed consent<\/b>. Am J Bioeth. 2012;12(3):33-4.\u00a0 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22416748<\/a><\/li>\n
  4. Hussain, MZ.\u00a0 Effect of Shape of Medication in Treatment of Anxiety States<\/b>. The British Journal of Psychiatry (1972) 120: 507-509.\u00a0 http:\/\/bjp.rcpsych.org\/content\/120\/558\/507.short<\/a><\/li>\n
  5. Jacobs, KW & Nordan, FM.\u00a0 Classification of Placebo Drugs: Effect of Color<\/b>. Perceptual and Motor Skills: Volume 49, Issue , pp. 367-372.\u00a0 http:\/\/journals.lww.com\/psychopharmacology\/Abstract\/1982\/08000\/…<\/a><\/li>\n
  6. Kam-Hansen, S. Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks<\/b>. \u00a0Sci Transl Med\u00a08 January 2014:\u00a0Vol.\u00a06\u00a0no.\u00a0218\u00a0pp.\u00a0218ra5. \u00a0http:\/\/stm.sciencemag.org\/content\/6\/218\/218ra5.full.html<\/a>)<\/li>\n
  7. Kaptchuk TJ, Friedlander E, Kelley JM, Sanchez MN, Kokkotou E, et al. Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome<\/b>. PLoS ONE 5(12): e15591.\u00a0http:\/\/www.plosone.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pone.0015591<\/a><\/li>\n
  8. Kaptchuk TJ<\/a>, et al.\u00a0 Sham device v inert pill: randomised controlled trial of two placebo treatments<\/b>.\u00a0 BMJ. 2006 Feb 18;332(7538):391-7.\u00a0 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16452103<\/a><\/li>\n
  9. Kelley, JM, et al.\u00a0 Patient and practitioner influences on the placebo effect in irritable bowel syndrome<\/b>.\u00a0 Psychosom Med. 2009 Sep;71(7):789-97. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19661195<\/a><\/li>\n
  10. Lang, EV, et al.\u00a0 Can words hurt? Patient-provider interactions during invasive procedures<\/b>.\u00a0 Pain. 2005 Mar;114(1-2):303-9. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15733657<\/a><\/li>\n
  11. Meyers, SS, et al.\u00a0 Patient expectations as predictors of outcome in patients with acute low back pain<\/b>.\u00a0 J Gen Intern Med. 2008 Feb;23(2):148-53. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18066631<\/a><\/li>\n
  12. Srivastava, RK & More, AT. Some Aesthetic Considerations for Over the Counter (OTC) pharmaceutical Products<\/b>. \u00a0International Journal of Biotechnology, 2010. \u00a0http:\/\/www.sciencedaily.com\/releases\/2010\/11\/101115110959.htm<\/a><\/li>\n
  13. Waber, RL, et al.\u00a0 Commercial Features of Placebo and Therapeutic Efficacy<\/b>.\u00a0 JAMA. 2008;299(9):1016-1017.\u00a0http:\/\/jama.jamanetwork.com\/article.aspx?articleid=181562<\/a><\/li>\n
  14. Wells, RE & Kaptchuk, TJ.\u00a0 To tell the truth, the whole truth, may do patients harm: the problem of the nocebo effect for informed consent<\/b>. Am J Bioeth. 2012;12(3):22-9.\u00a0 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22416745<\/a><\/li>\n
  15. Winslow, R.\u00a0 Placebos Might Work Even Better With a Brand Name.<\/b>\u00a0Health Blog.\u00a0Wall Street Journal, March 4, 2008.\u00a0 http:\/\/blogs.wsj.com\/health\/2008\/03\/04\/placebos-might-work-even-better-with-a-brand-name\/<\/a><\/li>\n
  16. Zimmermann-Viehoff, F.\u00a0Expensive placebos–what is free, what is without value<\/b>.\u00a0 Forsch Komplementmed. 2008 Oct;15(5):288-9.\u00a0 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19009728<\/a><\/li>\n
  17. Several pharmaceutical package inserts were also utilized in preparing this piece. \u00a0These include but are not limited to those available online for: rizatriptan, high-potency capsaicin, fluoxetine HCl\u00a0and sildenafil citrate.<\/li>\n<\/ol>\n

    ______________________________________________________________________________________________<\/span><\/p>\n<\/div>\n

    \n
    \"Reed<\/a>
    Reed Levine MD<\/figcaption><\/figure>\n

    Reed Loring Levine, MD, ABPN is a Board-Certified Neurologist and Pain Management Specialist who serves as the Director of Medical Education of a large subspecialty private practice medical group. \u00a0Actively engaged in clinical research, he formerly served as an elected council member of the Pain and Palliative Care Section of the American Academy of Neurology and has published over a dozen peer-reviewed scientific articles and textbook chapters and been interviewed by national publications including TIME Magazine and The Huffington Post.\u00a0 He has a dog, who is an untraditional beauty.<\/p>\n<\/div>\n<\/div>\n

    <\/div>\n
    <\/div>\n","protected":false},"excerpt":{"rendered":"

    Everyone knows what the \u201cplacebo-effect\u201d is, but most people know very little about how and why placebos work, how they can be tweaked or manipulated to alter our perceptions and behaviors.<\/p>\n","protected":false},"author":55,"featured_media":168,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,7,32,26],"tags":[47,49,43,44,46,45,48,50],"class_list":["post-167","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured","category-medicine","category-reed-levine","category-skepticism","tag-drugs","tag-health","tag-medicine-2","tag-placebo","tag-placebo-effect","tag-placebos","tag-rx","tag-skepticism-2"],"_links":{"self":[{"href":"https:\/\/skepticink.com\/health\/wp-json\/wp\/v2\/posts\/167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/skepticink.com\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/skepticink.com\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/skepticink.com\/health\/wp-json\/wp\/v2\/users\/55"}],"replies":[{"embeddable":true,"href":"https:\/\/skepticink.com\/health\/wp-json\/wp\/v2\/comments?post=167"}],"version-history":[{"count":0,"href":"https:\/\/skepticink.com\/health\/wp-json\/wp\/v2\/posts\/167\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/skepticink.com\/health\/wp-json\/wp\/v2\/media\/168"}],"wp:attachment":[{"href":"https:\/\/skepticink.com\/health\/wp-json\/wp\/v2\/media?parent=167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/skepticink.com\/health\/wp-json\/wp\/v2\/categories?post=167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/skepticink.com\/health\/wp-json\/wp\/v2\/tags?post=167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}